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Open-label Extension Study of Seralutinib in Adult Subjects With PAH (PROSERA-EXT)Recruiting
NCT06274801Phase 3Updated Jul 29, 2026
Sponsor: Gossamer Bio USA, Inc.
Pulmonary Arterial Hypertension
United States, Argentina, Australia, Belgium, Brazil +25 more
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell DiseaseRecruiting
NCT06975865Phase 3Updated Jul 29, 2026
Sponsor: Sanofi
Sickle Cell Disease
United States, Belgium, Brazil, France, Germany +8 more
A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal CancerRecruiting
NCT07525206Phase 3Updated Jul 29, 2026
Sponsor: AbbVie
Colorectal Cancer
United States, Belgium, Greece, Japan, Portugal +3 more
Depemokimab in Participants With Hypereosinophilic Syndrome, Efficacy, and Safety TrialRecruiting
NCT05334368Phase 3Updated Jul 29, 2026
Sponsor: GlaxoSmithKline
Hypereosinophilic Syndrome
United States, Argentina, Australia, Belgium, Brazil +16 more
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 MutationsRecruiting
NCT04293562Phase 3Updated Jul 29, 2026
Sponsor: Children's Oncology Group
Acute Myeloid Leukemia
United States, Australia, Canada, Puerto Rico
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)Recruiting
NCT07044336Phase 3Updated Jul 29, 2026
Sponsor: AstraZeneca
Endometrial Cancer · Malignant Solid Tumour
United States, Argentina, Australia, Austria, Belgium +23 more
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric SubjectsRecruiting
NCT05156398Phase 3Updated Jul 29, 2026
Sponsor: Pfizer
Migraine
United States, Canada, France, Italy, Japan +2 more
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)Recruiting
NCT07100080Phase 2, Phase 3Updated Jul 29, 2026
Sponsor: Bristol-Myers Squibb
Non-Small Cell Lung Cancer
United States, Argentina, Belgium, Canada, Chile +20 more
KYSA-6: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, in Patients With Generalized Myasthenia GravisRecruiting
NCT06193889Phase 2, Phase 3Updated Jul 29, 2026
Sponsor: Kyverna Therapeutics
Myasthenia Gravis · Generalized Myasthenia Gravis
United States, Australia, Brazil, Germany, Saudi Arabia +1 more
A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple SclerosisRecruiting
NCT07225504Phase 3Updated Jul 29, 2026
Sponsor: Novartis Pharmaceuticals
Secondary Progressive Multiple Sclerosis (SPMS)
United States, Argentina, Australia, Austria, Belgium +27 more
A Study to Investigate Efficacy, Safety and Tolerability of Barzolvolimab Versus Placebo in Adults With Cold Induced Urticaria and Symptomatic Dermographism Inadequately Controlled by H1-antihistamines (EMBARQ - ColdU and SD)Recruiting
NCT07266402Phase 3Updated Jul 29, 2026
Sponsor: Celldex Therapeutics
Chronic Inducible Urticaria · Cold Urticaria · Cold-Induced Urticaria · Symptomatic Dermographism
United States, Germany, Lithuania, Poland, South Africa +2 more
A Study to Evaluate Efficacy, Safety, and PK of XEMBIFY®+Standard Medical Treatment (SMT) Compared to Placebo+SMT to Prevent Infections in Participants With HGG and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia, Multiple Myeloma, and Non-Hodgkin LymphomaRecruiting
NCT05645107Phase 3Updated Jul 29, 2026
Sponsor: Grifols Therapeutics LLC
Hypogammaglobulinemia · Bacterial Infections · B-cell Chronic Lymphocytic Leukemia · Multiple Myleoma
United States, Bosnia and Herzegovina, Bulgaria, Croatia, Hungary +3 more
Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.Recruiting
NCT07319208Phase 3Updated Jul 29, 2026
Sponsor: Nantes University Hospital
TBI Traumatic Brain Injury
France
A Study to Investigate the Efficacy, Safety and Tolerability of Remibrutinib Versus Placebo in Adult Patients With Generalized Myasthenia GravisRecruiting
NCT06744920Phase 3Updated Jul 29, 2026
Sponsor: Novartis Pharmaceuticals
Generalized Myasthenia Gravis
United States, Argentina, Australia, Belgium, Brazil +15 more
Pelacarsen Roll-over Extension ProgramRecruiting
NCT06875973Phase 3Updated Jul 29, 2026
Sponsor: Novartis Pharmaceuticals
Atherosclerotic Cardiovascular Disease
United States, Puerto Rico
A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)Recruiting
NCT07099898Phase 3Updated Jul 29, 2026
Sponsor: GlaxoSmithKline
Neoplasms, Lung
Argentina, Australia, Brazil, Bulgaria, Canada +19 more
A Study to Test the Efficacy and Safety of Riliprubart Against the Usual Treatment of Intravenous Immunoglobulin (IVIg) in People With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)Recruiting
NCT06290141Phase 3Updated Jul 29, 2026
Sponsor: Sanofi
Chronic Inflammatory Demyelinating Polyneuropathy
United States, Argentina, Belgium, Brazil, Canada +18 more
A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear PalsyRecruiting
NCT07498426Phase 3Updated Jul 29, 2026
Sponsor: Novartis Pharmaceuticals
Progressive Supranuclear Palsy Richardson Syndrome (PSP-RS)
United States, Australia, China, France, Germany +5 more
Biologic Augmentation of TMJ Arthroscopy Using BMACRecruiting
NCT07536399Phase 3Updated Jul 29, 2026
Sponsor: Weill Medical College of Cornell University
TMJ - Oral &Maxillofacial Surgery · Oral and Maxillofacial Conditions · TMJ Pain · TMJ Arthralgia
United States
A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's DiseaseRecruiting
NCT07011745Phase 3Updated Jul 29, 2026
Sponsor: Bristol-Myers Squibb
Alzheimer's Disease
United States, Argentina, Chile, Czechia, France +9 more
Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After ImmunotherapyRecruiting
NCT07106762Phase 2, Phase 3Updated Jul 29, 2026
Sponsor: Bristol-Myers Squibb
Urothelial Cancer
United States, Argentina, Australia, Austria, Belgium +17 more
Study of Volrustomig in Women With High Risk Locally Advanced Cervical Cancer (eVOLVE-Cervical)Recruiting
NCT06079671Phase 3Updated Jul 29, 2026
Sponsor: AstraZeneca
Locally Advanced Cervical Cancer
United States, Brazil, Canada, China, Denmark +14 more
Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate: Exploring Its Role in Optimizing Surgical OutcomesRecruiting
NCT07733167Phase 3Updated Jul 29, 2026
Sponsor: Benha University
Intra-Prostatic Epinephrine Injection in Bipolar Transurethral Resection of Large Prostate
Egypt
eValuating the Efficacy and Safety of InitiatinG depemokImab earLy therApy iN Chronic Obstructive Pulmonary Disorder (COPD) With Type 2 InflammationRecruiting
NCT07177339Phase 3Updated Jul 28, 2026
Sponsor: GlaxoSmithKline
Pulmonary Disease, Chronic Obstructive
United States, Australia, Bulgaria, Canada, China +8 more
A 52-week Study of Rilzabrutinib Efficacy and Safety Compared to Placebo in Adults Diagnosed With IgG4-related DiseaseRecruiting
NCT07190196Phase 3Updated Jul 28, 2026
Sponsor: Sanofi
Immunoglobulin G4 Related Disease
United States, Argentina, Belgium, Canada, Chile +14 more

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