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An Efficacy and Safety Study of Clemizole HCl in Patients With Lennox-Gastaut SyndromeRecruiting
NCT05066217Phase 3Updated Aug 21, 2026
Sponsor: Epygenix
Lennox Gastaut Syndrome
United States, China, Italy, Poland, Romania +2 more
A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic MigraineRecruiting
NCT05711394Phase 3Updated Aug 21, 2026
Sponsor: AbbVie
Episodic Migraine
United States, Belgium, Canada, Denmark, France +11 more
Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's DiseaseRecruiting
NCT07378644Phase 2, Phase 3Updated Aug 21, 2026
Sponsor: Skyhawk Therapeutics, Inc.
Huntington Disease
United States, Argentina, Brazil, Canada, Chile +2 more
A Study of Eptinezumab in Pediatric Participants With Episodic MigraineRecruiting
NCT05897320Phase 3Updated Aug 21, 2026
Sponsor: H. Lundbeck A/S
Episodic Migraine
United States, Argentina, Canada, Italy, Mexico +6 more
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)Recruiting
NCT07165028Phase 3Updated Aug 21, 2026
Sponsor: Eli Lilly and Company
Metabolic Dysfunction-Associated Steatotic Liver Disease
United States, Argentina, Australia, Austria, Belgium +29 more
Study of Zoldonrasib + Chemo of Investigator's Choice vs Placebo + Chemo of Investigator's Choice as First-line Treatment in Metastatic KRAS G12D-mutated Pancreatic Adenocarcinoma ( RASolute 305 )Recruiting
NCT07621718Phase 3Updated Aug 21, 2026
Sponsor: Revolution Medicines, Inc.
Pancreatic Cancer · Pancreatic Cancer Metastatic · PDAC · PDAC - Pancreatic Ductal Adenocarcinoma
United States
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic MigraineRecruiting
NCT04965675Phase 3Updated Aug 21, 2026
Sponsor: H. Lundbeck A/S
Chronic Migraine in Children
United States, Argentina, Canada, Italy, Mexico +6 more
Phase IIIb Study of Ribociclib + ET in Early Breast CancerRecruiting
NCT05827081Phase 3Updated Aug 21, 2026
Sponsor: Novartis Pharmaceuticals
Early Breast Cancer
United States, Argentina, Australia, Brazil, Canada +11 more
SAFE Study: Safety of aPCC Following Emicizumab ProphylaxisRecruiting
NCT04563520Phase 3Updated Aug 21, 2026
Sponsor: Emory University
Hemophilia A
United States
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 DiabetesRecruiting
NCT07321886Phase 3Updated Aug 21, 2026
Sponsor: Eli Lilly and Company
Obesity · Overweight
United States, Argentina, Australia, Belgium, Brazil +10 more
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA MutationRecruiting
NCT06952803Phase 3Updated Aug 21, 2026
Sponsor: AstraZeneca
Prostate Cancer
United States, Argentina, Australia, Austria, Belgium +23 more
EEG-MRI Imaging of Methylphenidate Effects in Adult ADHD and Attentional Symptoms in Mood DisordersRecruiting
NCT05832489Phase 3Updated Aug 21, 2026
Sponsor: University Hospital, Strasbourg, France
Adult ADHD · Adult-onset ADHD With Mood Disorder
France
A Study to Assess Efficacy and Safety of Efgartigimod PH20 SC PFS in Adult Participants With Graves' Disease.Recruiting
NCT07596849Phase 3Updated Aug 21, 2026
Sponsor: argenx
Graves Disease
Canada, Georgia, Japan
Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT ImagingRecruiting
NCT07613099Phase 3Updated Aug 21, 2026
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Allogeneic Stem Cell Transplantation · Lung Allograft Transplantation · Interstitial Lung Disease · Acute Lung Injury
United States
Optimizing Hydroxyurea Dosage With Pharmakokinetic in Patients Suffering of Moderate to Severe Sickle Cell AnemiaRecruiting
NCT06761560Phase 2, Phase 3Updated Aug 21, 2026
Sponsor: Yves Pastore
Sickle Cell Disease (SCD)
Canada
A Study of Brenipatide in Participants With Alcohol Use DisorderRecruiting
NCT07219953Phase 3Updated Aug 21, 2026
Sponsor: Eli Lilly and Company
Alcohol Use Disorder
United States, Belgium, China, Germany, Japan +3 more
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL StudyRecruiting
NCT04269902Phase 3Updated Aug 21, 2026
Sponsor: National Cancer Institute (NCI)
Chronic Lymphocytic Leukemia · Small Lymphocytic Lymphoma
United States, Canada
LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver FibrosisRecruiting
NCT06632444Phase 3Updated Aug 21, 2026
Sponsor: Boehringer Ingelheim
Metabolic Dysfunction Associated Steatohepatitis (MASH) · Liver Fibrosis
United States, Argentina, Australia, Austria, Belgium +31 more
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)Recruiting
NCT05714085Phase 2, Phase 3Updated Aug 21, 2026
Sponsor: Merck Sharp & Dohme LLC
Heart Failure · Left Ventricular Systolic Dysfunction
United States, Belgium, Brazil, Canada, Colombia +25 more
A Clinical Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (MK-7962-038)Recruiting
NCT07218029Phase 3Updated Aug 21, 2026
Sponsor: Merck Sharp & Dohme LLC
Pulmonary Arterial Hypertension
United States, Argentina, Australia, Belgium, Brazil +22 more
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart FailureRecruiting
NCT06424288Phase 3Updated Aug 21, 2026
Sponsor: Boehringer Ingelheim
Heart Failure
United States, Argentina, Australia, Belgium, Brazil +25 more
A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)Recruiting
NCT07190248Phase 3Updated Aug 21, 2026
Sponsor: Merck Sharp & Dohme LLC
Non-small Cell Lung Cancer
United States, Argentina, Australia, Austria, Belgium +24 more
A Clinical Trial of Sac-TMT in People With Non-HRD Positive Advanced Ovarian Cancer (MK-2870-021)Recruiting
NCT07318558Phase 3Updated Aug 21, 2026
Sponsor: Merck Sharp & Dohme LLC
Ovarian Neoplasms · Ovarian Cancer
United States, Argentina, Australia, Austria, Belgium +24 more
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary TractRecruiting
NCT07218380Phase 3Updated Aug 21, 2026
Sponsor: Eli Lilly and Company
Carcinoma, Transitional Cell · Urinary Bladder Neoplasms · Neoplasm Metastasis
United States, Australia, Brazil, Canada, China +14 more
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular EventsRecruiting
NCT07136012Phase 3Updated Aug 21, 2026
Sponsor: Amgen
Cardiovascular Disease
United States, Australia, Canada

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