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OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

NCT07136012

RecruitingPhase 3

Sponsor: Amgen

Conditions: Cardiovascular Disease

Interventions: Olpasiran, Placebo

Countries: United States, Australia, Canada

The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).

Eligibility overview

Sex: ALL

Age: 50 Years to 105 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Age ≥50 years
* Lp(a)≥ 200 nmol/L during screening
* Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis

Exclusion Criteria:

* Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
* Prior or planned arterial revascularization
* History of major bleeding disorder
Locations (252)
  • Alexander City, Alabama, United States
  • Birmingham, Alabama, United States
  • Birmingham, Alabama, United States
  • Daphne, Alabama, United States
  • Fairhope, Alabama, United States
  • Huntsville, Alabama, United States
  • Mobile, Alabama, United States
  • Phoenix, Arizona, United States
  • Phoenix, Arizona, United States
  • Phoenix, Arizona, United States
  • Scottsdale, Arizona, United States
  • Tucson, Arizona, United States
  • Little Rock, Arkansas, United States
  • Beverly Hills, California, United States
  • Inglewood, California, United States
  • La Jolla, California, United States
  • Los Angeles, California, United States
  • Northridge, California, United States
  • Roseville, California, United States
  • San Diego, California, United States
  • Spring Valley, California, United States
  • Stanford, California, United States
  • Stockton, California, United States
  • Vista, California, United States
  • Walnut Creek, California, United States
  • West Hills, California, United States
  • West Hills, California, United States
  • Colorado Springs, Colorado, United States
  • Littleton, Colorado, United States
  • Greenwich, Connecticut, United States
  • + 222 more on CT.gov