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A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)Recruiting
NCT06951711Phase 3Updated Aug 18, 2026
Sponsor: Bristol-Myers Squibb
Bipolar Disorder Type I With Mania or Mania With Mixed Features
United States, China, Croatia, India, Israel +6 more
Adaptive Platform Trial of Treatments for Respiratory Infections in Community Settings (TreatResp)Recruiting
NCT07314905Phase 3Updated Aug 18, 2026
Sponsor: Unity Health Toronto
Influenza A · Influenza B · SAR-CoV-2 · Acute Respiratory Infections (ARIs)
Canada
Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized LipodystrophyRecruiting
NCT07220785Phase 3Updated Aug 18, 2026
Sponsor: Regeneron Pharmaceuticals
Generalized Lipodystrophy
United States, Brazil, France
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCDRecruiting
NCT05431088Phase 2, Phase 3Updated Aug 18, 2026
Sponsor: Pfizer
Sickle Cell Disease
United States, Brazil, India, Kenya, Nigeria +2 more
A Study to Evaluate V181 Dengue Vaccine in Healthy Participants 2 to 17 Years of Age (V181-005/MOBILIZE-1)Recruiting
NCT07013487Phase 3Updated Aug 18, 2026
Sponsor: Merck Sharp & Dohme LLC
Healthy
Indonesia, Malaysia, Philippines, Puerto Rico, Singapore +2 more
A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants With Metastatic Castration-resistant Prostate CancerRecruiting
NCT06764485Phase 3Updated Aug 18, 2026
Sponsor: Celgene
Metastatic Castration-resistant Prostate Cancer
United States, Argentina, Australia, Austria, Brazil +21 more
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated HeadacheRecruiting
NCT06621329Phase 2, Phase 3Updated Aug 18, 2026
Sponsor: University of California, Davis
SAH (Subarachnoid Hemorrhage) · Headache
United States
Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMRecruiting
NCT05902169Phase 3Updated Aug 18, 2026
Sponsor: CarThera
Glioblastoma · Recurrent Glioblastoma · GBM
United States, Austria, Belgium, Denmark, France +6 more
A Study to Evaluate the Drug Levels, Efficacy and Safety of Deucravacitinib in Children and Adolescent Participants With Moderate to Severe Plaque PsoriasisRecruiting
NCT04772079Phase 3Updated Aug 18, 2026
Sponsor: Bristol-Myers Squibb
Plaque Psoriasis
Argentina, Australia, Brazil, Canada, France +8 more
A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)Recruiting
NCT06615479Phase 3Updated Aug 18, 2026
Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Relapsed or Refractory Multiple Myeloma (RRMM)
United States, Argentina, Australia, Austria, Belgium +26 more
Study to Evaluate the Efficacy and Safety of Deuruxolitinib in Japanese Adults With Severe Alopecia AreataRecruiting
NCT07617597Phase 3Updated Aug 18, 2026
Sponsor: Sun Pharma Japan Limited
Alopecia Areata
Japan
Bedaquiline Roll-out Evidence in Contacts and People Living With HIV to Prevent TBRecruiting
NCT06568484Phase 2, Phase 3Updated Aug 18, 2026
Sponsor: Johns Hopkins University
Tuberculosis, Latent
Mongolia, Peru, Tanzania, Uganda
Short-Course Radiotherapy Followed by CAPOX With or Without Iparomlimab and Tuvonralimab in pMMR/MSS Locally Advanced Rectal CancerRecruiting
NCT07686640Phase 3Updated Aug 18, 2026
Sponsor: Shandong Cancer Hospital and Institute
Local Advanced Rectal Cancer · Radiotherapy · Immunotherapy
China
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionRecruiting
NCT06736574Phase 3Updated Aug 18, 2026
Sponsor: Cytokinetics
Heart Failure · Heart Failure With Reduced Ejection Fraction
United States, Canada, China, France, Germany +5 more
A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Appear in Babies With Genetically Diagnosed Spinal Muscular Atrophy (SMA)Recruiting
NCT07221669Phase 3Updated Aug 18, 2026
Sponsor: Biogen
Muscular Atrophy, Spinal
United States, Australia, Brazil, China, Japan
An Extension Study to Assess Safety and Efficacy of Remibrutinib in Participants With Moderate to Severe HSRecruiting
NCT07665437Phase 3Updated Aug 18, 2026
Sponsor: Novartis Pharmaceuticals
Hidradenitis Suppurativa
United States, Argentina, Australia, Canada
Evaluating the Safety and Efficacy of Duloxetine in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography PancreatitisRecruiting
NCT06860984Phase 3Updated Aug 18, 2026
Sponsor: Tanta University
Biliary Disease
Egypt
CompariSon Between the EuroPeAn and Japanese pathologiCal InvEstigation for Colon Cancer (SPACE)Recruiting
NCT06119867Phase 3Updated Aug 17, 2026
Sponsor: Russian Society of Colorectal Surgeons
Colonic Neoplasms
Russia
Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic CancerRecruiting
NCT06958328Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma · Stage II Pancreatic Cancer AJCC v8 · Stage III Pancreatic Cancer AJCC v8 · Stage IV Pancreatic Cancer AJCC v8
United States, Canada
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the BrainRecruiting
NCT06500455Phase 3Updated Aug 17, 2026
Sponsor: NRG Oncology
Anatomic Stage IV Breast Cancer AJCC v8 · Metastatic Breast Carcinoma · Metastatic Digestive System Carcinoma · Metastatic Lung Non-Small Cell Carcinoma
United States, Canada, Hong Kong, Ireland
A Long-term Study of the Medicine Called Abrocitinib in Children Aged 2 Years and Older With Moderate to Severe EczemaRecruiting
NCT06807281Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Atopic Dermatitis
United States, China, Germany, Hungary, Japan +3 more
A Clinical Study Evaluating the Efficacy and Safety of SHR-1819 Injection in Patients With Seasonal Allergic RhinitisRecruiting
NCT07688772Phase 3Updated Aug 17, 2026
Sponsor: Guangdong Hengrui Pharmaceutical Co., Ltd
Seasonal Allergic Rhinitis
China
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung CancerRecruiting
NCT07222566Phase 3Updated Aug 17, 2026
Sponsor: Pfizer
Advanced Non-Small Cell Lung Cancer · Non-Small Cell Lung Cancer · Carcinoma, Non-Small-Cell Lung · Carcinoma, Non-Small-Cell Lung (NSCLC)
United States, Argentina, Australia, Brazil, Canada +15 more
Complementary Herbal Approach to Rheumatoid Management Study (CHARMS)Recruiting
NCT07627893Phase 2, Phase 3Updated Aug 17, 2026
Sponsor: Singapore General Hospital
Rheumatoid Arthritis (RA)
Singapore
A Study to Investigate GB-0895 Adjunctive Therapy in Adults and Adolescents With Severe Uncontrolled Asthma (SOLAIRIA-2)Recruiting
NCT07359846Phase 3Updated Aug 17, 2026
Sponsor: Generate Biomedicines
Severe Asthma
United States, Argentina, Australia, Belgium, France +6 more

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