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Genetic of Skeletal Muscle Insulin Resistance

RecruitingNA

Sponsor: The University of Texas Health Science Center at San Antonio

Conditions: Insulin Stimulated

Interventions: Insulin 80mU/m2*min

Countries: United States

In this study, we will use euglycemic/hyperinsulinemic clamps, longitudinal skeletal muscle biopsies, and single nucleus RNA- and ATAC- sequencing to reveal cell type-specific molecular response Quantitative trait loci (rQTLs) acutely regulated by insulin signaling and glucose uptake.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Males and Females Age 18-75
* Body Mass Index (BMI) \> 18
* Normal glucose tolerance as defined by:

Fasting blood sugar \< 100 mg/dL 2-hour Oral Glucose Tolerance Test (OGTT) \< 140mg/dL Stable weight over the past 3 months defined as \>±5% change in body weight

* Hemoglobin A1c \< 5.7
* Creatinine \< 2
* Aspartate aminotransferase/Alanine transaminase (AST/ALT) \< 75
* Blood sodium 135 to 145 mEq/L
* Blood potassium 3.6 to 5.2 mmol/L\[MH1.1\]

Exclusion Criteria:

* Urine albumin excretion\>300mg/day
* Partial thromboplastin time (PTT) \>35International normalized ratio (INR) \> 1.2
* No oral corticosteroids for 1 month
* No Sodium-glucose co-transporter 2 (SGLT2) inhibitor for 3 months
* No glucagon-like peptide-1 (GLP-1) receptor agonist for 6 months
* Any anti-platelet or anti-coagulation medication other than as needed for Pain Management
* No alcohol 4 days before the insulin clamp and biopsy procedure
* No acute structural knee injuries
* No Rheumatologic muscular or nervous system disease
* Pregnancy, Intentions to become pregnant, or Breastfeeding
* Blood Pressure \>170/110
* Temperature \> 100F
* Triglycerides \> 400 by lipid panel
* Hemoglobin \<10g/dL
* 1+ or greater Blood on Urinalysis
* 2+ or greater Protein on Urinalysis
* Electrocardiogram (EKG) abnormalities, including but not limited to ST elevations, T wave abnormalities, evidence of recent prior infarct

Locations (1)

San Antonio, Texas, United States