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Magnesium Sulphate With Atropine and Pralidoxime vs Standard Therapy Alone in Acute Organophosphate Poisoning

RecruitingNA

Sponsor: Muhammad Aamir Latif

Conditions: Organophosphate Poisoning

Interventions: Atropine plus pralidoxime, Atropine and pralidoxime with adjunctive MgSO4

Countries: Pakistan

Pakistan, being a developing country, is one of the regions with the most cases of organophosphate (OP) poisoning/toxicity. MgSO4 is one of the most promising adjunctive treatments that needs to be tested. This study is being carried out with the objective of comparing the 15-day all-cause mortality rate and the total cumulative atropine requirement during hospitalization between patients receiving adjunctive magnesium sulphate with standard therapy and those receiving standard therapy alone.

Eligibility overview

Sex: ALL

Age: 18 Years to 50 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Both genders
* Adult patients aged between 18 and 50 years
* Confirmed clinical diagnosis of organophosphate poisoning containing insecticide, through the oral route
* Adult patients, or their legally authorized representative, who will provide informed consent to participate in the study

Exclusion Criteria:

* Patients with known allergy to MgSO4
* Patients with documented pre-existing renal impairment (Serum creatinine more than 1.5mg/dl)
* Patients with documented pre-existing cardiac impairments (e.g., heart block)
* Pregnant or lactating women
* Confirmed intake of any other drug or poison
* Patients who will be declared dead on arrival or those who expired within 2 hours of presentation

Locations (1)

Multan, Punjab Province, Pakistan