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Application of CT-Linac-Based "All-in-One" One-Stop Radiotherapy in Breast Cancer

RecruitingNA

Sponsor: Fudan University

Conditions: Breast Cancer

Interventions: Radiotherapy procedure

Countries: China

This study aims to evaluate and report the clinical adverse events and dosimetric parameters in breast cancer patients undergoing an "all-in-one (AIO)" one-stop, fully automated radiotherapy workflow. By systematically tracking these clinical and physical metrics, we seek to establish a standardized clinical protocol for AIO radiotherapy in breast cancer management.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Histologically or pathologically confirmed breast cancer with definitive indications for radiotherapy (preoperative, postoperative, or radical)
* ECOG performance status of 0-2
* Able to remain still and supine on the treatment couch for up to 30 minutes
* Provision of signed, written informed consent
* Able to comply with daily follow-ups and blood sample collections

Exclusion Criteria:

* Palliative radiotherapy for concurrent distant metastasis
* Incomplete or ongoing chemotherapy
* Synchronous multiple primary tumors
* Current pregnancy or lactation
* Prior history of radiotherapy to the ipsilateral breast, chest wall, thorax, or regional lymph nodes
* Severe non-malignant comorbidities (e.g., cardiovascular or pulmonary diseases, systemic lupus erythematosus, scleroderma) resulting in a short life expectancy or inability to tolerate radical radiotherapy
* Inability or unlikelihood to comply with study follow-up
* Inability or unwillingness to provide written informed consent

Locations (1)

Shanghai, Shanghai Municipality, China