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FABP4 Response After Roux-en-Y Gastric Bypass

CompletedN/A

Sponsor: Istanbul University

Conditions: Obesity (BMI>30), Obesity (BMI > 35), Insulin Resistance, Bariatric Surgery, Bariatric Surgery (Gastric Bypass)

This retrospective observational cohort study examined serum fatty acid-binding protein 4 (FABP4) dynamics in 28 adults who underwent Roux-en-Y gastric bypass (RYGB), followed at baseline, 3 months, and 6 months. Anthropometric, metabolic, and inflammatory parameters were assessed alongside FABP4, fasting GLP-1, and PYY. Patients were classified as FABP4 responders (decrease from baseline to 6 months) or rebound/non-responders. The study investigated whether FABP4 trajectory after RYGB is associated with the magnitude of weight loss, systemic inflammation, and fasting incretin change.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Adults who underwent Roux-en-Y gastric bypass (RYGB), performed by a single surgeon
* Completed baseline, 3-month, and 6-month clinical and anthropometric assessments

Exclusion Criteria:

* Use of GLP-1 receptor agonists at any study time point
* Use of insulin at any study time point
* Missing 6-month FABP4 measurement (excluded from FABP4-based longitudinal/group analyses; n=1)