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Cross-modal Neuromodulation to Improve Balance and Cognition in Older Adults With Glaucoma: A Randomized Trial of Cerebellar Transcranial Electrical Stimulation

NCT07771699

RecruitingNA

Sponsor: The Hong Kong Polytechnic University

Conditions: Glaucoma

Interventions: transcranial electrial stimulation

Countries: Hong Kong

The goal of this clinical trial is to use different tES techniques to constantly stimulate the cerebellum in older glaucoma patients. The main questions aim to answer : 1. If the different types of tES targeting the cerebellum can modulate glaucoma patients' balance function and visual-cognitive function? 2. Which tES techniques among the two types can benefit most? Participants will be required to receive the stimulation 15 times (3 sessions, 5 continuous days/session, 1-week interval between each session), and complete the balance and visual-cognitive function outcome measurements before and after each session.

Eligibility overview

Sex: ALL

Age: 55 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age over 55 years old;
* Diagnosis of primary open-angle or normal-tension glaucoma with relative scotoma in both eyes;
* Humphrey Field Analyzer visual field loss (mean deviation of ≤- 6 dB) using the 24-2 testing protocol for both eyes;
* Best-corrected distance visual acuity of 6/12 (equivalent to 0.3 logMAR) or better;
* Cognitive functional score of 22 or above in the Montreal Cognitive Assessment -Hong Kong version (HK-MoCA).
* Only the right-handed population will be recruited (screening by the Edinburgh Handedness Inventory).

Exclusion Criteria:

* Have musculoskeletal disorders or neurological diseases that can affect the balance or nervous system.
* Ocular diseases other than glaucoma (e.g., age-related macular degeneration, diabetic retinopathy, moderate to severe cataract) or severe hearing impairment (to ensure that participants can hear the instructions clearly during assessments and training)
* Have any contraindications for tES

Locations (1)

Kowloon, Hong Kong, Hong Kong