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Feasibility and Uptake of Low-Dose CT Lung Cancer Screening in Kuwait

Not Yet RecruitingNA

Sponsor: Sulaiman Khadadah

Conditions: Lung Cancer, Lung Neoplasms

Interventions: Low-dose computed tomography (LDCT) lung cancer screening

Countries: Kuwait

Lung cancer is a leading cause of cancer-related death in Kuwait, where most cases are diagnosed at an advanced stage and there is no national screening program. This prospective pilot feasibility study will offer low-dose computed tomography (LDCT) screening to approximately 500 high-risk individuals aged 50-80 years across Kuwait. The primary objective is to assess the uptake of, and barriers to, LDCT lung cancer screening in Kuwait and to establish a framework for a national screening program. Participants undergo eligibility assessment (smoking history of at least 20 pack-years, totalled across all tobacco products using pre-specified equivalency conversions for shisha/waterpipe, cigar, pipe, and roll-your-own tobacco), baseline assessment, LDCT screening with Lung-RADS-based management, a second screening round at 12 months, and follow-up. LDCT images are read by radiologists and in parallel by artificial intelligence (AI) software to evaluate AI-assisted reading. Findings will inform national lung cancer screening guidelines for Kuwait.

Eligibility overview

Sex: ALL

Age: 50 Years to 80 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Age 50 to 80 years
* Smoking history of at least 20 pack-years, totalled across all tobacco products using pre-specified equivalency conventions (1 shisha head-year = 1 pack-year; 1 cigar = 4 cigarettes; 1 pipe bowl = 2.5 cigarettes; roll-your-own tobacco 1 g = 1 cigarette). Current and former smokers are eligible regardless of time since quitting.
* Able to provide informed consent

Exclusion Criteria:

* Previous diagnosis of lung cancer
* Currently under surveillance for pulmonary nodules
* Currently undergoing diagnostic assessment, treatment, or surveillance for major comorbidities
* Unable to lie flat with arms raised above the head for CT scanning
* Symptoms suggestive of lung cancer (persistent or worsening cough, haemoptysis, or unexplained weight loss of more than 7 kg in the past year)

Locations (1)

Kuwait City, Kuwait