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Mapping the Neural Circuits of Depression and Anxiety Using Personalized, Accelerated TMS and Deep Phenotyping

Not Yet RecruitingNA

Sponsor: National University Hospital, Singapore

Conditions: Depression Disorder

Interventions: Individualized connectome-guided accelerated iTBS

Countries: Singapore

This proposal seeks to carry out a double-blinded, randomized, comparative study that investigates neurobehavioral changes induced by personalized, anxiosomatic and dysphoric network guided accelerated intermittent-theta burst (iTBS) using dense functional Magnetic Resonance Imaging (fMRI) sampling in participants with treatment-resistant depression (TRD) and moderate/high levels of anxiety.

Eligibility overview

Sex: ALL

Age: 21 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Male/female aged 21-70
* Diagnosis of MDD as validated by MINI
* Non-response to adequate trial (4 weeks) of at least two MDD medication as verified by the study clinician
* BDI score of 20 or above; BAI score of 16 or above
* Able to give informed consent
* Able to understand English

Exclusion Criteria:

* DSM-5 psychotic disorder
* Drug or alcohol abuse or dependence (preceding 3 months)
* Rapid clinical response required, e.g., high suicide risk
* Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy
* Metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump or other electronic device
* Pregnancy
* Unsuitable for MRI
* With recent TMS or ECT treatment in past 3 months
* Multiple stimulant medications

Locations (1)

Singapore, Singapore