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Role of N-Acetylcysteine in Non-Acetaminophen-Induced Liver Failure

RecruitingNA

Sponsor: King Edward Medical University

Conditions: Acute Liver Failure

Interventions: N Acetyl Cysteine, Standard supportive care

Countries: Pakistan

This randomized controlled trial evaluates whether oral N-acetylcysteine (NAC), given alongside standard supportive care, improves survival and reduces mortality in patients with non-acetaminophen-induced acute liver failure (ALF), compared to supportive care alone. Secondary objectives are to assess NAC's effect on length of hospital stay and improvement in liver function tests. Sixty-two adult patients (18-60 years) will be randomized 1:1 to NAC or control, with outcomes assessed at 28 days (survival/mortality) and day 4 (liver function tests).

Eligibility overview

Sex: ALL

Age: 18 Years to 60 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Male or female, aged 18-60 years
* Diagnosed with non-acetaminophen- induced acute hepatic failure (per operational definition/EASL criteria)
* Etiology other than acetaminophen overdose (viral hepatitis HAV/HBV/HEV, non-acetaminophen drug-induced liver injury, or idiopathic)
* No NAC treatment received for current episode prior to enrollment

Exclusion Criteria:

* History of chronic liver disease or cirrhosis
* Prior severe cardiac, renal, neurological, or infectious disease that could confound outcomes
* Prior liver transplant or current transplant candidacy
* Known allergy/contraindication to NAC
* Pregnant women.

Locations (1)

Lahore, Punjab Province, Pakistan