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Pneumococcal Carriage Duration

RecruitingN/A

Sponsor: University of Central Florida

Conditions: Pneumococcal Carriage

Interventions: Oropharyngeal (OP) swab

Countries: United States

Streptococcus pneumoniae (SPN) remains a leading cause of respiratory disease in young children despite widespread vaccination. Understanding the duration of pneumococcal carriage, patterns of co-colonization, and the influence of viral infections and the respiratory microbiome is essential to evaluate next-generation pneumococcal vaccines and inform public health strategies. Current data on Streptococcus pneumoniae carriage dynamics are limited in U.S. pediatric populations. This study aims to generate updated estimates of Streptococcus pneumoniae colonization and explore microbial interactions using high-resolution longitudinal sampling and genomic methods.

Eligibility overview

Sex: ALL

Age: 28 Days to 48 Months

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Are older than 28 days and under 4 years of age at the time of enrollment.
* Have a parent or legal guardian who:

  1. Provides written informed consent.
  2. Is able to read and speak English or Spanish.
  3. Agrees to comply with all study procedures, including completion of questionnaires and biweekly oropharyngeal (OP) swab collections from the child for a period of 12 months.

Exclusion Criteria:

* History of chronic medical conditions or immunocompromising conditions that may influence pneumococcal carriage or study participation, such as:
* cystic fibrosis
* cerebral palsy
* neuromuscular disorders
* congenital heart disease
* known congenital or acquired immunodeficiencies
* sickle cell disease
* undergoing immunosuppressive therapy (e.g., systemic corticosteroids ≥2 mg/kg/day for ≥14 days, chemotherapy, biologics)

Locations (1)

Orlando, Florida, United States