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Sponsor: National University of Natural Medicine
Conditions: Long COVID Fatigue
Interventions: Ketogenic Metabolic Therapy, Lifestyle Intervention
Countries: United States
The goal of this clinical trial is to learn if a 12-week ketogenic diet program combined with lifestyle strategies (called KMT-LS) is practical and acceptable as a fully remote intervention for adults with Long COVID who also have Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (ME/CFS) and dysautonomia (problems with heart rate, blood pressure, or other automatic body functions). The main questions it aims to answer are: Can a ketogenic diet program be successfully delivered entirely from home using online tools and virtual support? Do participants stay in the study, follow the diet, and find the program safe and satisfactory? Do participants experience improvements in fatigue, sleep, mood, daily functioning, and symptom flare-ups after exertion? Participants will: Follow a ketogenic diet for 12 weeks with weekly virtual nutrition support sessions Use at-home tools to track their ketone levels and confirm they are following the diet Complete online questionnaires about their symptoms, energy, sleep, mood, and daily functioning at the start of the study, after 12 weeks, and again 3 months later.
Sex: ALL
Age: 18 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: Age 18 years or older English-speaking Suspected, probable, or confirmed SARS-CoV-2 infection as defined by the Pan American Health Organization Long COVID diagnosed via structured clinical interview, consistent with the World Health Organization clinical case definition and the National Academies of Sciences, Engineering, and Medicine (2024) definition Physician-confirmed diagnosis of post-infectious dysautonomia and ME/CFS; OR self-reported dysautonomia symptoms with a Malmö POTS Score Assessment (MAPS) score greater than 40 Met the National Academy of Medicine diagnostic criteria for ME/CFS Exclusion Criteria: * Known pregnancy or planning pregnancy during the study period Active cancer diagnosis Renal or liver failure Pancreatitis Atrial fibrillation or significant cardiac arrhythmia Significant atherosclerotic disease Uncontrolled hypertension or hypertriglyceridemia Active or recent thrombosis Use of antiepileptic medications Use of SGLT-2 inhibitors Substance use disorder Type I diabetes History of inborn errors of metabolism Previous completion of a nutritional and lifestyle program for this condition
- Portland, Oregon, United States