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Assessing Treatment With High-phenolic EVOO Supplements for Neurovascular Activity

Not Yet RecruitingNA

Sponsor: Augusta University

Conditions: Mild Cognitive Impairment (MCI)

Interventions: EVOO-phenolics dietary supplement, Placebo

Countries: United States

The goal of this clinical trial is to determine whether the extra-virgin olive oil (EVOO) phenolic dietary supplement can improve memory function and modulate biomarkers among individuals with mild cognitive impairment (MCI). The main questions it aims to answer are: * Does dietary supplementation with EVOO phenolics improve cognitive function? * What would be the effect of the EVOO dietary supplement on other MCI-related biomarkers, including vascular function and biological pathways? Researchers will compare the EVOO dietary supplements with a placebo (a look-alike substance that contains no EVOO phenolics) Participants will: * Take EVOO dietary supplements or a placebo daily for 6 months * Visit the study site during the 6-month study for screening and testing.

Eligibility overview

Sex: ALL

Age: 50 Years to 70 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* CDR (Clinical Dementia Rating) score of 0.5 OR MoCA (Montreal Cognitive Assessment) score of 18-25.

Exclusion Criteria:

* History or presence of vascular disease that may affect cognitive function
* History or presence of stroke within the past 1 year
* Recent transient ischemic attack (TIA) within the past 180 days
* History of severe, clinically significant CNS trauma
* History of intracranial tumor
* History or presence of kidney disease (eGFR \<60 mL/min/1.73m2)
* Presence of a pacemaker
* Presence of metal in the body
* Allergic to the MRI contrast agent "Multihance"
* Pregnancy

Locations (1)

Augusta, Georgia, United States