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Vitamin D Status and Asthma Control, Pulmonary Function, and Oxidative Stress in Adults With Bronchial Asthma

Not Yet RecruitingN/A

Sponsor: Sinai University

Conditions: Bronchial Asthma, Vitamin D Deficiency, Pulmonary Function Impairment, Oxidative Stress, Asthma

Asthma is a chronic inflammatory airway disease associated with variable airflow limitation and persistent respiratory symptoms. Vitamin D has been proposed as a potential biomarker related to immune regulation, asthma control, pulmonary function, and oxidative stress balance. This prospective cross-sectional observational study aims to investigate the association between serum 25-hydroxyvitamin D \[25(OH)D\] concentrations, asthma control, pulmonary function parameters, and erythrocyte oxidative stress biomarkers among Egyptian adults with bronchial asthma. A total of 200 adult asthma patients will be recruited from Abbassia Chest Hospital, Cairo, Egypt. Participants will undergo clinical assessment, Asthma Control Test (ACT), post-bronchodilator spirometry, serum vitamin D measurement, and oxidative stress biomarker assessment including malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione (GSH). Participants will be categorized according to serum 25(OH)D concentrations into vitamin D deficient, insufficient, and sufficient groups. No intervention or treatment assignment will be performed. 5\. Detailed Description

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria

* Age ≥ 18 years.
* Confirmed diagnosis of bronchial asthma.
* Clinically stable at the time of assessment.
* Availability of spirometry results.
* Availability of laboratory investigations including serum 25(OH)D and oxidative stress biomarkers.

Exclusion Criteria

* Other chronic pulmonary diseases.
* Active respiratory infection.
* Malignancy.
* Significant renal or hepatic disease.
* Pregnancy.
* Current vitamin D supplementation.
* Other conditions known to markedly influence oxidative stress status.