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Inclusion Criteria:

* Aged between 30 and 75 years, regardless of gender
* Diagnosed with Parkinson's disease conforming to relevant clinical diagnostic standards with a medical history of 5-20 years
* Having received standard anti-PD treatment and been given optimal anti-PD treatment under the guidance of the investigator, but the efficacy has significantly declined
* Good response to levodopa medications, the levodopa challenge test (LCT) shows that the maximum improvement rate of the UPDRS-III score exceeds 30%
* The modified H\&Y staging (Off period) of ≥2.5 and ≤4, with total daily "off" time \>2 hours
* Stable dose of anti-Parkinson' disease drugs for at least 4 weeks prior to screening
* Good physical condition or stable concomitant diseases

Exclusion Criteria:

* The subjects with atypical Parkinson's syndrome or secondary Parkinson's syndrome
* Severe systemic diseases or functional impairments
* Evidence of active infection or chronic infection, which may pose a risk to the subject
* Severe concomitant central nervous system diseases or severe cognitive and psychiatric disorders
* Subjects with a history of brain injuries, cerebral vascular malformations, hydrocephalus, brain tumors, or other brain damages as shown by previous Head CT/MRI scans, or subjects with abnormal brain imaging in the striatum or other brain regions that significantly increase surgical risks
* Subjects who have participated in clinical trials for stem cell therapy or gene therapy for Parkinson's disease, or have participated in other interventional clinical trials within the last 3 months
* Subjects with a history of severe allergies or hypersensitivity reactions, known hypersensitivity to the investigational drug or its ancillary materials, or intolerance to them
* Pregnant or breastfeeding women

• Shanghai, China