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Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training
Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

NCT07721766

RecruitingNA

Sponsor: Technical University of Munich

Conditions: Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend

Interventions: Hypertrophy-focused Resistance Training

Countries: Finland, Germany, Ireland, Spain

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

Eligibility overview

Sex: ALL

Age: 18 Years to 39 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Body Mass Index (BMI) between 20-29 kg/m2
* No structured resistance training performed in the last twelve months.
* Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
* No history of competitive strength or physique sports.

Exclusion Criteria:

* Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
* Positive response to any question on the PAR-Q 2025 questionnaire.
* Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
* Regular engagement in shift work.
* Women who are pregnant or breastfeeding.
Locations (8)
  • Jyväskylä, Central Finland, Finland
  • München, Bavaria, Germany
  • Cologne, North Rhine-Westphalia, Germany
  • Düsseldorf, North Rhine-Westphalia, Germany
  • Chemnitz, Saxony, Germany
  • Leipzig, Saxony, Germany
  • Limerick, Limerick, Ireland
  • Madrid, Madrid, Spain