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Mild Cognitive Impairment and Neuromodulation

NCT07691918

Enrolling By InvitationNA

Sponsor: Virginia Polytechnic Institute and State University

Conditions: Mild Cognitive Impairment (MCI)

Interventions: Low intensity focused ultrasound, Sham (No Treatment)

Countries: United States

This is a parallel, sham-controlled design of low-intensity focused ultrasound in patients with mild cognitive impairment (MCI). The study will evaluate safety, tolerability, and effects on cognitive function.

Eligibility overview

Sex: ALL

Age: 55 Years to 80 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Montreal Cognitive Assessment (MoCA) scores between 18-23 inclusive, and able to consent to their own medical care.

Exclusion Criteria:

* Claustrophobia
* MRI contraindications (pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, or other implants)
* CT contraindications (pregnancy)
* Non-AD etiology (eg. Lewy body disease, vascular dementia, alcohol/drug related damage)
* Taking anti-amyloid antibodies
* Neuromod within 6 months of the study
* History of other neurological disorder
* Hx of head injury with LOC \> 10 min
* Active alcohol or drug dependence

Locations (1)

Roanoke, Virginia, United States