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Study of NTB-928 in R/R OC

RecruitingPhase 1

Sponsor: TeneoSeven, Inc.

Conditions: Relapsed/Refractory Ovarian Carcinoma

Interventions: NTB-928

Countries: United States

The goal of this clinical trial is to determine if NTB-928 can be given safely to adult females with ovarian cancer that has come back (relapsed) or stopped responding to treatment (refractory), how NTB-928 moves through the body, and how the immune system reacts to it. The study will also look for early signs of anti-cancer activity of NTB-928. The main questions the study aims to answer are: * What side effects do participants experience when receiving NTB-928, including side effects that limit how much of it can be safely given? * How is NTB-928 processed by the body at different dose levels? * Does the immune system react to NTB-928 during treatment? * What dose of NTB-928 can be given safely that shows early signs of activity against ovarian cancer?

Eligibility overview

Sex: FEMALE

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Aged 18 years or older
* Have a confirmed diagnosis of ovarian cancer, including high-grade serous, high-grade endometrioid, low-grade serous, or clear cell ovarian cancer, or carcinosarcoma of the ovary. Patients with mucinous carcinoma are not eligible.
* Have relapsed or refractory ovarian cancer and have already received standard treatments known to provide benefit; participants are eligible if they have platinum-refractory, platinum-resistant, or platinum-sensitive ovarian cancer (with clearly documented ineligibility for further platinum chemotherapy).
* Are able to understand the study requirements and are willing to provide written informed consent
* Are willing to use effective birth control during the study and for a period after the last dose of study treatment, if of childbearing potential

Exclusion Criteria:

* Have another active cancer that could interfere with assessment of this study treatment
* Have received another investigational drug or certain cancer treatments within a recent period before starting this study
* Are pregnant or breastfeeding

Locations (4)

Birmingham, Alabama, United States
Omaha, Nebraska, United States
Lake Success, New York, United States
Fort Worth, Texas, United States