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Cardiovascular Assessment 5 Years After MIS-C

RecruitingN/A

Sponsor: Medical University of Warsaw

Conditions: Multisystem Inflammatory Syndrome in Children (MIS-C), SARS-CoV-2 Infection

Countries: Poland

Multisystem inflammatory syndrome in children (MIS-C) is a severe complication associated with SARS-CoV-2 infection that frequently affects the cardiovascular system. Although acute cardiac abnormalities usually resolve, the long-term cardiovascular consequences of MIS-C remain uncertain. Previous follow-up of this cohort 2 years after MIS-C identified signs of subclinical cardiovascular abnormalities compared with healthy controls. This cross-sectional study aims to evaluate cardiovascular health in individuals 5 years after MIS-C. Participants with a history of MIS-C will be compared with age- and sex-matched healthy controls using cardiovascular imaging, vascular assessments, cardiopulmonary exercise testing, and biomarkers of endothelial injury.

Eligibility overview

Sex: ALL

Healthy volunteers: Yes

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* For the MIS-C group: History of MIS-C diagnosed according to World Health Organization (WHO) criteria
* For all participants: Written informed consent from a parent or legal guardian and, where applicable, assent/consent from participants aged 16 years or older /

Exclusion Criteria:

MIS-C group:

1. Known heart disease, including congenital heart disease.
2. Significant chronic disease affecting growth, development, or daily functioning.

Control group:

1. Elimination diet.
2. Competitive athletic training.
3. Known heart disease, including congenital heart disease.
4. Significant chronic disease affecting growth, development, or daily functioning.

Locations (1)

Warsaw, Masovian Voivodeship, Poland