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Interplay of Central and Peripheral Vascular Effects of Insulin in Obesity

NCT07653464

Not Yet RecruitingEARLY_Phase 1

Sponsor: University of Missouri-Columbia

Conditions: Obesity (BMI>30), Insulin Resistance

Interventions: human insulin

Countries: United States

Determine the impact of obesity with insulin resistance on the neurovascular response to brain insulin stimulation.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 18 to 65 years of age

Individuals with obesity and comorbid IR

* BMI 30-45 kg/m2
* Waist circumference ≥102 cm (men) or ≥88 cm (women)
* HOMA-IR ≥2.5

Healthy normal weight adults

* BMI 18-25 kg/m2
* Waist circumference \<94 cm (men) and \<80 cm (women)
* HOMA-IR \<2

Exclusion Criteria:

* Pregnancy, breastfeeding
* Unable to provide consent
* Diabetes or polycystic ovarian syndrome
* Known history of cardiovascular disease: heart failure, ischemic heart disease, peripheral artery disease, stroke
* Nerve/neurologic disease
* Uncontrolled hypertension (systolic blood pressure \>180 mmHg and/or diastolic blood pressure \>100 mmHg)
* Active cancer (excluding basal cell carcinoma or stage 1 squamous cell carcinoma of the skin)
* Current smoking, tobacco, nicotine use
* Use of pharmacological therapy for weight loss
* Body weight change \>10% within the last 6 months
* Adherence to \>150 min/week of moderate-to-vigorous physical activity/exercise
* Participation in any other research study or medical procedure involving significant ionizing radiation exposure in the past 12 months
* Claustrophobia
* Non-MRI compatible metal implants

Locations (1)

Columbia, Missouri, United States