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Biomarkers in Alzheimer's and Parkinson's Diseases for IA

Active Not RecruitingN/A

Sponsor: IRCCS San Raffaele Roma

Conditions: Parkinson Disease, Alzheimer Disease, Mild Cognitive Impairment, Dementia

Interventions: Neuropsycological assesment, cerebral MRI, EEG, Venous blood sample of 20ml, Sample collection of exfoliated buccal mucosa

Countries: Italy

Investigate whether endogenous and exogenous risk factors, the presence of pathological amyloid aggregates and alpha-synuclein in the CSF, brain connectivity, and some clinical and biological indices such as vigilance, general motility, the sleep-wake cycle, genomic instability and possible DNA damage may correlate with (or predict) the clinical condition of mild cognitive impairment (MCI) and dementia in patients with Alzheimer's disease (AD) and Parkinson's disease (PD).

Eligibility overview

Sex: ALL

Age: 60 Years to —

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* The subject must be over 60 years of age;
* The Subject must have a full understanding of the Italian language;
* The subject is available to participate in the phase telemonitoring.

Exclusion criteria:

* Inability to sign the informed consent;
* Severe dementia;
* Other concomitant diseases;
* Inability to participate in study procedures;
* Presence of arrhythmia, heart failure or previous heart attack, peripheral vascular disease or impaired circulation, valvular disease (diseases affecting the aortic valve), other diseases known conditions, end-stage renal disease (ESRD), diabetes, neurological disorders (e.g example, tremors), bleeding disorder or taking prescribed anticoagulants, tattoo(s) on the wrist where you will wear the Samsung Galaxy Watch, you will have an implanted pacemaker, a defibrillator implanted heart or other implanted electronic devices.

Locations (1)

Rome, Italy, Italy