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Evaluation of Time-Sensitive Nebulization Mode Converter

CompletedPhase 4

Sponsor: Beni-Suef University

Conditions: Aerosol Therapy, Asthma

Interventions: Cross-over Nebulization Modes Comparison System, Cross-over Nebulization Modes Comparison System

Countries: Egypt

This study utilizes a randomized crossover design to evaluate and compare the clinical and technical efficacy of different nebulization modes for aerosol drug delivery. By implementing a within-subject comparison, each participant will receive the two designated aerosol delivery interventions under distinct, controlled protocols. The primary objective is to determine whether synchronization of aerosol generation with the inspiratory phase could improve respirable aerosol delivery, enhance pulmonary drug deposition, and reduce aerosol loss during exhalation without significantly altering aerosol aerodynamic particle size distribution characteristics. This research aims to optimize nebulization practices and establish evidence-based guidelines for enhanced respiratory drug administration.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Mild to moderate asthmatic patients.

Exclusion Criteria:

* Severe asthmatic patients.
* Patients admitted to an intensive care unit
* Ischemic heart disease.
* Recent abdominal surgery.
* Hepatic or renal impairment.
* Hypersensitivity to salbutamol

Locations (1)

Banī Suwayf, Beni Suweif Governorate, Egypt