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Intermittent Low Oxygen Breathing: A First Study Testing Different Disease Stages in People Living With MS

Not Yet RecruitingPhase 1, Phase 2

Sponsor: University of Saskatchewan

Conditions: Multiple Sclerosis

Interventions: Acute Intermittent Hypoxia

This study will look at the safety, tolerability and feasibility of a non-invasive treatment called Acute Intermittent Hypoxia (AIH) in people with Multiple Sclerosis (MS) at different stages of the disease course.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

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Group 1:

* People with a confirmed diagnosis of MS and advanced disability level (Expanded Disability Status Scale (EDSS) \>6.5 and \<9)
* Without relapse for at least 90 days prior
* Older than age 18

Group 2:

* People with a confirmed diagnosis of relapsing remitting MS
* Acute disabling relapse onset within the past 4 weeks. A disabling relapse will be defined as at least 1.0-point increase on the EDSS.
* Older than age 18

Group 3:

* People with a confirmed diagnosis of MS that is non-active and progressive (Primary or Secondary Progressive MS). Non-active will be defined as without MS relapse, new/enlarging or enhancing MRI lesions within the past 1 year.
* EDSS \<=6.5
* Older than age 18

Exclusion Criteria:

* Pregnancy
* Any of the following documented respiratory disorders: obstructive sleep apnea, chronic obstructive pulmonary disease, uncontrolled asthma, hypoxic pulmonary disease, respiratory infection in the previous 3 months
* Ischemic cardiac disease
* Cardiac arrhythmia
* Severe hypertension (\>160/100)
* Seizure disorders
* Medically unstable in another capacity
* Unable to provide informed consent