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Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age

RecruitingNA

Sponsor: Vietnam Military Medical University

Conditions: Male Infertility, Advanced Paternal Age, Assisted Reproductive Technology

Interventions: LensHooke® CA0 sperm sorting device, Density Gradient Centrifugation

Countries: Vietnam

Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF/ICSI cycles involving men aged 40 years or older

Eligibility overview

Sex: ALL

Age: 40 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Male partners aged ≥ 40 years
* Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million/mL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence.
* Female partners with ≥ 5 mature (MII) oocytes retrieved.
* Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET).
* Willingness to participate and sign informed consent.

Exclusion Criteria:

* Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm.
* Female uterine or ovarian conditions severely affecting IVF outcomes.
* Use of donor sperm or donor oocytes

Locations (1)

Hà Nội, Ha Dong, Vietnam