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Sponsor: Hitit University
Conditions: Chronic Obstructive Pulmonary Disease (COPD), Asthma
Countries: Turkey (Türkiye)
This observational study evaluates whether dynamic inspiratory muscle strength can be estimated in patients with chronic obstructive pulmonary disease (COPD) and asthma using simple clinical and performance-based measurements. Dynamic inspiratory muscle strength was assessed using the S-Index, which reflects the pressure generated during a fast and forceful inspiration while airflow is maintained. The study included adult male patients diagnosed with COPD or asthma. Participants completed respiratory muscle strength assessment, pulmonary function testing, body composition assessment, and a fixed-pressure inspiratory muscle performance test using a threshold loading device set at 30 cmH₂O. The number of inspiratory repetitions performed until task failure and related respiratory variables were recorded. The main aim of the study was to develop prediction models for estimating S-Index values from accessible measures such as peak inspiratory flow, inspiratory repetition performance, spirometry parameters, and body composition variables. The study may help determine whether dynamic inspiratory muscle strength can be estimated in clinical settings where direct S-Index measurement devices are not available.
Sex: MALE
Age: 18 Years to —
Healthy volunteers: No
Study type: OBSERVATIONAL
Inclusion Criteria: * Being 18 years of age or older * Having a clinical diagnosis of chronic obstructive pulmonary disease or asthma * Being able to perform fixed-pressure inspiratory muscle loading and S-Index measurements in accordance with the instructions and with correct technique * Having experienced no additional clinical condition within the previous 12 weeks, apart from the existing chronic respiratory disease, that could acutely affect respiratory function * Having signed the informed consent form approved by the ethics committee Exclusion Criteria: * Smoking * Inability to perform fixed-pressure inspiratory muscle loading or dynamic respiratory muscle strength assessment according to the technical requirements of the measurement protocols * Inability to obtain reliable data due to insufficient coordination, motivation, or volitional effort * Presence of a musculoskeletal injury or surgical history affecting the diaphragm, thorax, spine, or abdominal region that could significantly impair respiratory mechanics * Presence of neurological conditions that may affect respiratory muscle function, such as neuromuscular diseases, peripheral nerve damage, or central nervous system disorders
- Çorum, Turkey (Türkiye)