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A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight
A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

NCT07589608

RecruitingPhase 2

Sponsor: Eli Lilly and Company

Conditions: Overweight, Obesity

Interventions: Macupatide, Eloralintide, Placebo

Countries: United States

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Eligibility overview

Sex: ALL

Age: 18 Years to 75 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* See Master Protocol CWMM (NCT06143956) for inclusion criteria

Exclusion Criteria:

In addition to exclusion criteria in Master Protocol CWMM (NCT06143956):

* Have type 1 diabetes or type 2 diabetes
* Have an ongoing history of bradyarrhythmia and/or sinus bradycardia
* Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm)
* Have a history of acute or chronic pancreatitis
* All concomitant medications should be at a stable dose for at least 3 months prior to screening
Locations (40)
  • Chandler, Arizona, United States
  • Scottsdale, Arizona, United States
  • Tucson, Arizona, United States
  • Greenbrae, California, United States
  • Huntington Park, California, United States
  • Rolling Hills Estates, California, United States
  • Walnut Creek, California, United States
  • Stamford, Connecticut, United States
  • Miami, Florida, United States
  • Miami Lakes, Florida, United States
  • New Port Richey, Florida, United States
  • Orlando, Florida, United States
  • The Villages, Florida, United States
  • Ammon, Idaho, United States
  • Chicago, Illinois, United States
  • Topeka, Kansas, United States
  • Louisville, Kentucky, United States
  • Needham, Massachusetts, United States
  • New Bedford, Massachusetts, United States
  • Southfield, Michigan, United States
  • Troy, Michigan, United States
  • City of Saint Peters, Missouri, United States
  • Springfield, Missouri, United States
  • Las Vegas, Nevada, United States
  • Amherst, New York, United States
  • Rochester, New York, United States
  • Greensboro, North Carolina, United States
  • Monroe, North Carolina, United States
  • Morehead City, North Carolina, United States
  • New Bern, North Carolina, United States
  • + 10 more on CT.gov