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Nutritional Status and Muscle Function in Ambulatory Multiple Sclerosis Patients With Dysphagia

Enrolling By InvitationN/A

Sponsor: Sanko University

Conditions: Multiple Sclerosis, Nutrition, Swallowing

Countries: Turkey (Türkiye)

The aim of this study is to evaluate the relationship between dysphagia severity and indicators of nutritional status and muscle function in ambulatory patients diagnosed with Multiple Sclerosis (MS) who have swallowing difficulties. In patients with MS, the prevalence of swallowing disorders increases with disease duration and greater neurological involvement. Dysphagia may lead to important clinical consequences such as aspiration risk, inadequate oral intake, involuntary weight loss, and reduced quality of life. Swallowing difficulties negatively affect both the adequacy and safety of nutrition, thereby increasing the risk of malnutrition. In addition, reduced energy and protein intake may lead to a decline in muscle strength and functional capacity. However, in the MS population, dysphagia, nutritional status, and muscle function are often evaluated separately, and studies that assess these domains together are limited. There is a need for real-world data in ambulatory MS patients, particularly using age-independent nutritional screening tools and functional muscle assessment tests in combination. This study aims to systematically and multidisciplinary evaluate nutritional status and muscle function in MS patients with dysphagia.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

1. Be 18 years of age or older
2. Have a diagnosis of multiple sclerosis according to the 2017 Revised McDonald criteria
3. Have difficulty swallowing (DYMUS \>1)
4. EDSS score must be available in clinical records
5. Possess sufficient cognitive and physical capacity to participate in the questionnaires and assessments to be administered as part of the study

Exclusion Criteria:

* 1\. A recent acute MS relapse or use of high-dose corticosteroids within the past 4 weeks 2. Acute orthopedic or traumatic conditions that prevent the performance of measurements 3. Severe cognitive impairment that prevents understanding or performing the tests 4. Being pregnant or breastfeeding 5. Presence of active malignancy or advanced systemic disease 6. Having any pathology in the cervical region

Locations (1)

Gaziantep, şehitkamil, Turkey (Türkiye)