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Bilateral Anodal Cerebellar tDCS for Multidomain Dysfunctions in Patients With Multiple Sclerosis

Not Yet RecruitingNA

Sponsor: University of Sharjah

Conditions: Multiple Sclerosis

Interventions: Bilateral Cerebellar Transcranial Direct Current Stimulation (ctDCS), Sham Bilateral Cerebellar tDCS

Countries: United Arab Emirates

The goal of this clinical trial is to learn if brain stimulation can improve movement and daily function in people with multiple sclerosis (MS). The study will also look at how this treatment affects fatigue, sleep, memory and attention, and quality of life. The main questions this study aims to answer are the following: Does this treatment improve coordination and balance? Does it reduce fatigue and improve sleep and daily life? Does it change brain activity? Researchers will compare active brain stimulation to sham stimulation (a look-alike treatment that does not deliver real stimulation) to see if the treatment works. Participants will: Receive brain stimulation sessions for two weeks Attend assessment sessions before and after treatment Return for a follow-up visit after four weeks Complete tests of movement, fatigue, sleep, and thinking

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Confirmed diagnosis of Multiple Sclerosis according to the revised McDonald criteria
* Adult Age \> 18 years
* Expanded Disability Status Scale (EDSS) score between 2.0 and 6.0
* Clinically stable disease status for at least 3 months prior to enrollment
* On stable disease-modifying therapy (DMT) for at least 3 months
* Ability to understand study procedures and provide informed consent
* Ability to ambulate independently or with assistive devices sufficient to complete motor assessments

Exclusion Criteria:

* Multiple sclerosis relapse within the past 3 months
* History of epilepsy or seizures
* Presence of implanted electronic devices (e.g., pacemaker, neurostimulator)
* Metallic implants in the head or skull incompatible with transcranial magnetic stimulation (TMS)
* Severe cognitive impairment preventing participation in assessments
* Pregnancy or planned pregnancy during the study period
* Other neurological or psychiatric disorders that may confound study outcomes
* Severe musculoskeletal or orthopedic conditions interfering with motor performance testing
* Contraindications to non-invasive brain stimulation or TMS

Locations (1)

Sharjah city, United Arab Emirates