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Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study

RecruitingN/A

Sponsor: Vastra Gotaland Region

Conditions: Respiratory Distress Syndrome (& [Hyaline Membrane Disease]), Respiratory Distress Syndrome (Neonatal), Respiratory Distress Syndrome (RDS), Respiratory Distress Syndrome of Newborn, Respiratory Distress Syndrome in Premature Infant

Countries: Sweden

The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS). Preterm infants often have immature lungs and a deficiency of surfactant, a substance that helps keep the lungs open and supports oxygen exchange.Surfactant can be delivered to the lungs using different techniques, including INSURE (brief intubation), LISA (via a thin catheter), SALSA (via a laryngeal mask airway), and traditional administration via endotracheal intubation followed by mechanical ventilation. The main question this study aims to answer is:Which method of surfactant administration is associated with better clinical outcomes in preterm infants with RDS?The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register. The results are intended to be used to inform the design of a future randomized multicenter study.

Eligibility overview

Sex: ALL

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Patient has received surfactant by any administration method
* Gestational age below 37 weeks'
* First surfactant treatment given before 48 hours of age
* Confirmed or suspected diagnosis of respiratory distress syndrome (RDS)

Exclusion Criteria:

• Not fulfilling above inclusion criteria

Locations (1)

Gothenburg, Sweden