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Sponsor: Zhejiang Provincial Tongde Hospital
Conditions: Alzheimer Disease, Cognitive Dysfunction, Mild Cognitive Impairment
Interventions: Scenario-Based Reenactment Training, Usual Care
Countries: China
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, including impairments in orientation, memory, and daily functioning. Orientation dysfunction, involving difficulties in recognizing time, place, and person, is a common and clinically significant feature in patients with mild to moderate AD. This study aims to evaluate the effectiveness of a scenario-based reenactment training program in improving cognitive function and orientation ability in patients with mild to moderate Alzheimer's disease. The intervention is based on patients' real-life experiences and uses personalized visual materials (e.g., photos and videos) to reconstruct familiar scenarios, thereby enhancing cognitive stimulation and environmental recognition. In this prospective controlled study, participants will be assigned to either a scenario-based training group or a usual care group. The intervention group will receive structured training sessions three times per week for 3 months, followed by a 6-month follow-up period. The control group will receive standard care without structured cognitive training. The primary outcome is global cognitive function assessed by the Montreal Cognitive Assessment (MoCA). Secondary outcomes include orientation function, depressive symptoms, anxiety levels, quality of life, and intervention feasibility. This study aims to provide evidence for a practical, non-pharmacological intervention to improve cognitive and functional outcomes in patients with Alzheimer's disease.
Sex: ALL
Age: 60 Years to —
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Age ≥ 60 years * Diagnosis of mild to moderate Alzheimer's disease according to DSM-5 criteria * Ability to communicate and complete cognitive assessments * Stable caregiver available to assist with intervention and follow-up * Visual and auditory function adequate to participate in assessments (with or without correction) * Willingness to participate and provide informed consent (by patient or legal guardian) Exclusion Criteria: * Severe psychiatric disorders (e.g., severe depression, schizophrenia) * Severe cardiovascular, cerebrovascular, or other systemic diseases affecting participation * History of neurological disorders other than Alzheimer's disease (e.g., Parkinson's disease, stroke with major deficits) * Severe sensory impairment (vision or hearing) that interferes with intervention or assessment * Inability to complete study procedures or comply with follow-up * Participation in other interventional clinical trials within the past 3 months
- Hangzhou, Zhejiang, China