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Sponsor: Instituto Nacional de Enfermedades Respiratorias
Conditions: Supplemental Nutrition Assistance Program Education, Post COVID Syndrome, Endothelial Function
Interventions: L-citrulline supplementation
Countries: Mexico
This study aims to evaluate the impact of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical functionality in recovered COVID-19 patients. The primary research question is: What is the effect of a non-pharmacological treatment (nutritional therapy and pulmonary rehabilitation) on endothelial function, body composition, and physical capacity in recovered COVID-19 patients, compared to those receiving conventional medical management? A nutritional treatment combined with L-citrulline supplementation (intervention group) will be compared against conventional treatment alone (control group). Both groups will undergo pulmonary rehabilitation for a 3-month follow-up. Subjects assigned to the intervention group will be required to: * Take 4 g of L-citrulline daily for 3 months. * Attend an interim session at 1.5 months for review of the nutritional treatment and supplementation. * Keep a record of each supplement intake.
Sex: ALL
Age: 40 Years to 80 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Recovered COVID-19 patients with a negative PCR test for SARS-CoV-2. * Subjects between 40 and 80 years. * Subjects who give written informed consent to participate in the study. Exclusion Criteria: * Subjects diagnosed with Human Immunodeficiency Virus (HIV). * Subjects diagnosed with cancer. * Subjects with a glomerular filtration rate (GFR) \<30 ml/min/1.73 m². * Subjects currently enrolled in another interventional study.
- Mexico City, Mexico