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A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris
A Phase 2/3 Study of Brepocitinib in Adults With Lichen Planopilaris

NCT07532603

RecruitingPhase 2, Phase 3

Sponsor: Priovant Therapeutics, Inc.

Conditions: Lichen Planopilaris

Interventions: Oral Brepocitinib, Placebo

Countries: United States, Australia, Canada, United Kingdom

This study will evaluate the clinical safety and efficacy of oral brepocitinib in participants with lichen planopilaris

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

1. Age ≥ 18 years
2. Scalp biopsy consistent with LPP
3. Active and symptomatic LPP at screening and baseline-
4. Weight \> 40 kg to \< 130 kg with BMI ≤ 45 kg/m2

Exclusion Criteria:

1. History of: Lymphoproliferative disorder; Active malignancy; History of cancer within 5 years prior to baseline (exceptions for basal cell carcinoma, squamous cell carcinoma, ductal carcinoma in situ of the breast, carcinoma in situ of the uterine cervix, or thyroid cancer).
2. High risk of thrombosis or cardiovascular disease
3. High risk of herpes zoster
4. Active or recent infection
Locations (61)
  • Birmingham, Alabama, United States
  • Phoenix, Arizona, United States
  • Scottsdale, Arizona, United States
  • Irvine, California, United States
  • Oakland, California, United States
  • Sacramento, California, United States
  • San Francisco, California, United States
  • Denver, Colorado, United States
  • Farmington, Connecticut, United States
  • New Haven, Connecticut, United States
  • Miami, Florida, United States
  • Chicago, Illinois, United States
  • Skokie, Illinois, United States
  • Clarksville, Indiana, United States
  • Indianapolis, Indiana, United States
  • Leawood, Kansas, United States
  • Louisville, Kentucky, United States
  • Boston, Massachusetts, United States
  • Burlington, Massachusetts, United States
  • Ann Arbor, Michigan, United States
  • Ann Arbor, Michigan, United States
  • Medina, Minnesota, United States
  • Minneapolis, Minnesota, United States
  • Kansas City, Missouri, United States
  • Lee's Summit, Missouri, United States
  • Lebanon, New Hampshire, United States
  • New Hyde Park, New York, United States
  • New York, New York, United States
  • Durham, North Carolina, United States
  • Cleveland, Ohio, United States
  • + 31 more on CT.gov