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Impact of Exercise Training on Serum Neurofilament Light Chain (NfL), Brain Volumetry, and Functional Outcomes in Multiple Sclerosis

NCT07520812

Not Yet RecruitingNA

Sponsor: Firat University

Conditions: Multiple Sclerosis, Exercise, Neurofilament Light Chain

Interventions: Exercise

Countries: Turkey (Türkiye)

This single-blind, randomized controlled trial will employ a two-arm parallel design (exercise group vs. control group) with a 12-week intervention period. Randomization will be implemented using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) to ensure balanced group allocation. All outcome measures will be assessed at baseline and post-intervention.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Clinically confirmed relapsing-remitting multiple sclerosis (RRMS) diagnosis according to revised McDonald criteria (2017)
* Mild-to-moderate disability (EDSS score 1.0-5.5)
* No corticosteroid treatment within the previous 3 months

Exclusion Criteria:

* Acute MS relapse within 90 days prior to enrollment
* Regular participation in structured exercise programs (\>3 hours/week)
* Comorbid conditions that may limit exercise participation, including; significant orthopedic impairments, unstable cardiopulmonary conditions and other systemic disorders affecting physical activity
* Standard MRI contraindications (metallic implants, claustrophobia, etc.)
* Concurrent neurological disorders (other than MS)
* Initiation or modification of disease-modifying therapy within 6 months
* Severe spasticity (Modified Ashworth Scale ≥3 in any major muscle group)

Locations (1)

Elâzığ, Turkey (Türkiye)