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AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss
AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

NCT07503210

RecruitingPhase 3

Sponsor: Novo Nordisk A/S

Conditions: Obesity

Interventions: NNC0487-0111, Placebo (matched to NNC0487-0111)

Countries: United States, Argentina, Australia, Belgium, Bulgaria, Denmark, France, Germany

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria
Inclusion Criteria:

* Male or female (sex at birth).
* Age 18 years or above at the time of signing the informed consent.

Exclusion Criteria:

* Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening.
* History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
* Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.
Locations (72)
  • Anniston, Alabama, United States
  • Walnut Creek, California, United States
  • Orlando, Florida, United States
  • Skokie, Illinois, United States
  • Indianapolis, Indiana, United States
  • Greensboro, North Carolina, United States
  • Wilmington, North Carolina, United States
  • Philadelphia, Pennsylvania, United States
  • Cumberland, Rhode Island, United States
  • Dallas, Texas, United States
  • Dallas, Texas, United States
  • Winchester, Virginia, United States
  • Renton, Washington, United States
  • Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
  • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
  • Mar del Plata, Buenos Aires, Argentina
  • Buenos Aires, Argentina
  • Campbelltown, New South Wales, Australia
  • Liverpool, New South Wales, Australia
  • Merewether, New South Wales, Australia
  • Adelaide, South Australia, Australia
  • Diepenbeek, Belgium
  • Kortrijk, Belgium
  • Liège, Belgium
  • Ostend, Belgium
  • Lom, Bulgaria
  • Plovdiv, Bulgaria
  • Plovdiv, Bulgaria
  • Plovdiv, Bulgaria
  • Sofia, Bulgaria
  • + 42 more on CT.gov