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Skeletal Muscle Aging and Responsiveness in Aged People With MS

RecruitingNA

Sponsor: Oklahoma Medical Research Foundation

Conditions: Multiple Sclerosis, Aging

Interventions: Exercise trial consisting of both cardiovascular and strength training

Countries: United States

The purposes of this study are to: 1) compare baseline muscle and cardiovascular health in older individuals (\>60 years old) diagnosed with MS to age-matched people without MS, 2) determine muscle and whole body changes to an exercise training program, 3) determine if the muscle in a more affected leg in individuals diagnosed with MS is different from the muscle of a less affected leg, and 4) if or how individuals diagnosed with MS adapt differently than age-matched people without MS to exercise training. Participation in this study will average 1.5 hours per visit, 3 visits per week, for approximately 4 months.

Eligibility overview

Sex: ALL

Age: 60 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* 1\. Male or female aged 60 or above 2. Free of unmanaged chronic diseases other than multiple sclerosis 3. No structured exercise program (2 or more bouts/wk) within previous 6 months 4. Cognitively capable of providing informed consent 5. Must meet EDSS score between 2 to 5.5 during screening

Exclusion Criteria:

* 1\. Neuromuscular or musculoskeletal disorder, other than multiple sclerosis, that would limit the ability to perform the exercise and/or testing bouts.

2\. Cardiopulmonary disorders or reduced breathing capacity

3\. Metabolic diseases including markers of liver disease (ALT \> 52 U/dl) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)

4\. Taking any dose of metformin

5\. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, Alzheimer's, current cancer diagnosis or within 2 yr remission, cerebrovascular)

6\. History of Chemotherapy within 5 years

7\. Unchangeable anticoagulant (Coumadin, Pradaxa, etc.) use. To be determined by clinical staff.

8\. Insulin sensitizing/blood glucose lowering (e.g., metformin) or metabolic (GLP1 agonists) drugs.

9\. High dose statin (40 mg and above)

10\. Have a non-correctable visual impairment

11\. Score less than 29 on the Symbol Digit Test

12\. Received Botox for spasticity within the prior 3 months of study participation.

13\. Cannot have any adjustments to Baclofen during study participation.

13\. Unable to commit to \~4 months required to complete the study.

14\. Lidocaine allergy

15\. Tobacco use

16\. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/day or drinks/wk for males)

17\. BMI greater than 35.0 kg/m2

Locations (1)

Oklahoma City, Oklahoma, United States