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Vegan Diet and Immune-Inflammatory Outcomes in Asthma and Healthy Adults

Not Yet RecruitingNA

Sponsor: Medical University of Gdansk

Conditions: Asthma, Dietary Intervention, Vegan Diet

Interventions: Omnivorous diet, Vegan diet

This randomized controlled study evaluates the effects of a balanced vegan diet compared with a balanced omnivorous diet on inflammatory and immune response markers and clinical asthma parameters in healthy adults and individuals with mild to moderate asthma, aged 18 to 50. Participants will follow assigned dietary plans for 12 weeks with dietitian support delivered via digital tools.

Eligibility overview

Sex: ALL

Age: 18 Years to 50 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

For all groups:

* Aged 18-30 years
* Willing to adhere to assigned dietary plan (vegan or omnivorous) for 12 weeks
* Non-smoker for at least 5 years
* Body mass index (BMI) between 18.5 and 24.9 kg/m2

For the asthma group:

* Clinical diagnosis of mild or moderate asthma (GINA criteria), made at least 12 months before enrollment
* Stable asthma status (no exacerbations or changes in therapy within the past 3 months)
* No change in pharmacotherapy during the study period

Exclusion Criteria:

* Use of systemic corticosteroids (oral or intravenous) within the past 3 months
* Ongoing biological therapy for asthma (e.g., anti-IgE, anti-IL-5, anti-IL-4R)
* Severe asthma as per GINA criteria
* Recent asthma exacerbation requiring hospitalization or steroid burst (\<3 months)
* Presence of other chronic autoimmune or inflammatory diseases
* Pregnancy or lactation
* Active infection or acute illness at the time of recruitment
* Adherence to specialized exclusion diets (e.g., ketogenic, low-FODMAP)
* History of eating disorders
* Inability or unwillingness to participate in follow-up visits or comply with the protocol