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HIV Pre-Exposure Prophylaxis (PrEP) Linkage With Immediate Medications in the Emergency Department Study

RecruitingNA

Sponsor: University of Texas Southwestern Medical Center

Conditions: HIV Pre-exposure Prophylaxis, PrEP

Interventions: PrEP Uptake with Rapid Start, Pre-Exposure Prophylaxis (PrEP) Persistence

Countries: United States

Our primary objective is to increase HIV pre-exposure prophylaxis (PrEP) awareness and uptake among people who want, need, or would benefit from PrEP in Dallas, TX through a pilot program of immediate PrEP prescribing in the Parkland Memorial Hospital Emergency Department (ED) with linkage to PrEP clinic. Leveraging the previous work of the Parkland Center for Clinical Innovation (PCCI) which created an automated electronic health record (EHR) based HIV prediction tool and prior success with a robust ED HIV navigation program, a PrEP navigator would approach patients in the Parkland ED for PrEP initiation. Through standard care prescribing by their ED clinician, subjects would leave the ED with a prescription for rapid-start oral PrEP and a clinic appointment to persist on the PrEP modality of their choice which will include long-acting injectable options.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Primary study (ED patients):

Inclusion Criteria:

* Able to comprehend and provide signed, written informed consent prior to initiation of study procedures.
* Negative HIV rapid test
* At least one of the following criteria:

  * Requesting PrEP from their ED clinician
  * Score \>75% on the PCCI HIV Prediction Tool
  * Prior bacterial STI diagnosis
  * Seeking STI testing
  * Referred by their ED clinician as someone who otherwise meets a CDC PrEP indication

Exclusion Criteria:

* Known diagnosis of HIV
* Positive HIV rapid test
* Current use of PrEP, which is defined for purposes of this study as use of PrEP in the last 4 weeks
* Known hypersensitivity or allergy to any PrEP modality
* People who do not want to follow with Parkland ID clinic for ongoing PrEP care
* Adults unable to consent, people under the age of 18, women who are known to be pregnant or breast feeding at time of study enrollment, or prisoners

Sub-study subjects (ED clinicians):

Inclusion criteria:

• Clinician in the Parkland ED

Exclusion criteria:

• People under the age of 18 or prisoners.

Locations (1)

Dallas, Texas, United States