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Sponsor: VA Office of Research and Development
Conditions: Multiple Sclerosis
Interventions: Effect of Exercise with and Without Cognitive Training on Gait
Countries: United States
This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.
Sex: ALL
Age: 55 Years to 85 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * US Veteran * Diagnosis of Multiple Sclerosis * Relapse free in the last 30 days * Capable of standing unaided for at least 1 minute * Expanded Disability Status Scale \<6.5 * Ability to speak and understand English Exclusion Criteria: * Any neurological disorder other than MS * Modified Telephone Interview for Cognitive Status \<20 * Current participation in an exercise or cognitive rehabilitation study
- Decatur, Georgia, United States