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A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

NCT07435194

Active Not RecruitingPhase 1

Sponsor: Merck Sharp & Dohme LLC

Conditions: Healthy

Interventions: MK-2828, Itraconazole, Midazolam

Countries: United States

The main goals of this study are: * To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole * To learn what happens to one dose of midazolam in a healthy person's body over time when it is taken with MK-2828 Researchers want to learn if the levels of MK-2828 in the body are about the same when MK-2828 is taken with itraconazole as when it is taken alone. They also want to know if taking MK-2828 more than once affects how much midazolam is in the body after a single dose.

Eligibility overview

Sex: ALL

Age: 24 Years to 60 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

The main inclusion criteria include but are not limited to the following:

\- Participant is in good health

Exclusion Criteria:

The main exclusion criteria include but are not limited to the following:

* History of cancer (malignancy)
* History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases

Locations (1)

Madison, Wisconsin, United States