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Sponsor: Saglik Bilimleri Universitesi
Conditions: Parkinson Disease (PD), Periodontitis, Periodontal Diseases
Countries: Turkey (Türkiye)
The aim of this study is to evaluate the effects of Levodopa-Benserazide drug combination on periodontal status and salivary cytokine levels in patients with Parkinson's disease. The study includes four groups: Parkinson's patients with periodontitis, periodontally healthy Parkinson's patients, participants without Parkinson's with periodontitis, and periodontally healthy participants without Parkinson's. Clinical periodontal parameters (Plaque Index, Gingival Index, Bleeding on Probing, Pocket Depth, and Clinical Attachment Loss) will be recorded. Unstimulated saliva samples will be collected to analyze the levels of TNF-alpha, RANTES, IL-10, IL-13, Total Oxidant Status (TOS), Total Antioxidant Status (TAS), and Malondialdehyde (MDA).
Sex: ALL
Healthy volunteers: Yes
Study type: OBSERVATIONAL
Inclusion Criteria: * Diagnosis of Parkinson's Disease according to United Kingdom Parkinson's Disease Society Brain Bank Criteria (for study group). * Systemically healthy individuals (for control group). * Willingness to participate and sign informed consent. Exclusion Criteria: * Active smoking. * Comprehensive periodontal treatment within the last month. * Oral, respiratory, or digestive system diseases within the last 3 months. * Fewer than 16 natural teeth. * Use of full or removable partial dentures. * Dementia or inability to provide consent. * Serious active illnesses or substance abuse. * Antibiotic treatment within the last 3 months. * Probiotic use within the last month. * Radiotherapy/chemotherapy within the last 6 months. * Use of oral antiseptics within the last month. * Diabetes mellitus.
- Ankara, Turkey (Türkiye)