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Sponsor: Merck Sharp & Dohme LLC
Conditions: Healthy
Interventions: MK-4082, Placebo
Countries: United States
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time
Sex: ALL
Age: 18 Years to 60 Years
Healthy volunteers: Yes
Study type: INTERVENTIONAL
Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Is in good health * Has body mass index (BMI) between 25 and 40 kg/m\^2, inclusive. Participants must weigh at least 60 kg Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * has a history of previous surgical treatment for obesity (bariatric surgery, gastric banding, etc.) or any other gastrointestinal (GI) surgery that may induce malabsorption, history of bowel resection \>20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss (including LAP-BAND®), as well as clinically significant GI disorders (eg, peptic ulcers, severe gastroesophageal reflux disease) * has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2
- Anaheim, California, United States
- Chula Vista, California, United States
- South Miami, Florida, United States
- Springfield, Missouri, United States
- Marlton, New Jersey, United States