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Effects of Muscle Cooling on Motor Unit Firing of the Quadriceps

NCT07381920

SuspendedNA

Sponsor: Wake Forest University

Conditions: Healthy

Interventions: Cryotherapy

Countries: United States

The overall objective of this pilot study is to establish the feasibility and methodological validity of using high-density surface electromyography to characterize motor unit behavior of the quadriceps under thermoneutral and locally cooled conditions, and to generate preliminary data to inform the design of a larger, hypothesis-driven study.

Eligibility overview

Sex: ALL

Age: 18 Years to 35 Years

Healthy volunteers: Yes

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Men and women between the ages of 18 and 35 years
* Healthy adults, defined as absence of significant acute/chronic medical condition, injury, and/or illness that may compromise subject safety, limit the ability of the participant to complete the study, and/or compromise the objectives of the study as determined by the Principal Investigator.

Exclusion Criteria:

* Current diagnosis or history of:

  * major metabolic disease (e.g., type I and type II diabetes),
  * neuromuscular disease (e.g., cervical spondylotic radiculomyelopathy, lumbar spondylosis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and acquired demyelinating polyneuropathies),
  * cardiovascular disease (e.g., stage II hypertension, heart failure, myocardial infarction/ischemia, peripheral vascular disease, Raynaud's phenomenon, or other conditions associated with impaired peripheral circulation),
  * significant myocardial or pericardial diseases (e.g. amyloidosis, constriction),
  * moderate or severe valvular disease,
  * pulmonary/respiratory disease (e.g., asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease),
  * cancer,
  * renal disease,
  * liver disease,
  * or anemia.
* Current or recent musculoskeletal injury (e.g. fracture, sprain, dislocation) or any physical disability that precludes safe and adequate testing.
* Pregnancy or breastfeeding.
* Thigh circumference greater than 23 inches
* Mid-thigh skinfold thickness greater 40 mm

Locations (1)

Winston-Salem, North Carolina, United States