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Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study

Enrolling By InvitationN/A

Sponsor: Ellen Margrethe Hauge

Conditions: Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder, Anxiety Disorders

Countries: Denmark

The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that includes comprehensive baseline and follow-up assessments at 3, 5, and 10 years. It comprises a main protocol and several optional modules, including a Cardiac Imaging Module, Biobanking Module, Pulmonary Module, and Anxiety and Depression Module. The study aims to advance understanding of cardiopulmonary and psychological comorbidities in rheumatoid arthritis, to improve early identification and management, and to enhance insights into underlying disease mechanisms-ultimately refining risk stratification and targeted prevention strategies. The study includes 4,000 patients with rheumatoid arthritis enrolled through the Cardiac Imaging Module in the main protocol. Participants undergo coronary computed tomography angiography, pulmonary function testing, physical examination, questionnaires, and biobanking, supplemented by genetic, proteomic, metabolomic, and microbiome profiling.

Eligibility overview

Sex: ALL

Age: 50 Years to 75 Years

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Fulfill the ACR/EULAR-2010 criteria for rheumatoid arthritis
* Attending or has attended at least one visit during the last two years in rheumatology outpatient clinic for diagnostic or monitoring purposes related to rheumatoid arthritis
* Age 50-75 years

Exclusion Criteria:

* Diagnosed with overlapping systemic autoimmune diseases other than secondary Sjogren's syndrome
* Active cancer
* Prior coronary atherosclerotic symptoms as defined by myocardial infraction, percutaneous coronary intervention, or coronary artery bypass grafting
* Allergy to radiocontrast agents
* Estimated glomerular filtration rate (eGFR) \< 30 mL/min
* BMI \> 35 kg/m2
* Persistent atrial fibrillation

Locations (4)

Aarhus, Denmark
Esbjerg, Denmark
Herning, Denmark
Herning, Denmark