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Sponsor: Lokman Hekim University
Conditions: Multiple Sclerosis
Interventions: aerobic exercise intervention
Countries: Turkey (Türkiye)
This study is a randomised controlled trial designed to thoroughly investigate the effects of aerobic exercise on NVU biomarkers in individuals with MS. The study was conducted between February and June 2025 at the MS clinic affiliated with the Department of Neurology, Faculty of Medicine, Ondokuz Mayıs University. Participants were randomly assigned to either a control group or an exercise group. Assessments were conducted at baseline (pre-assessment) and eight weeks after the intervention (post-assessment).
Sex: ALL
Age: 20 Years to 50 Years
Healthy volunteers: No
Study type: INTERVENTIONAL
Inclusion Criteria: * Having a definite diagnosis of MS according to McDonald criteria, * Being aged between 20 and 50, * Having a Standardised Mini Mental Test (SMMT) score of ≥24, * Having an Expanded Disability Status Scale (EDSS) score between 0 and 4.0, * Having no other serious health problems that would prevent exercise, * Having had no change in medication in the last 6 months. Exclusion Criteria: * Having experienced an MS relapse within the last 6 months, * Having an orthopaedic or systemic problem that would prevent participation in the exercises, * Having another known neuromuscular disorder besides MS, * Having received immunomodulatory treatment within the last 6 months, * Having a cardiopulmonary disorder that could prevent participation in the exercise, * Being pregnant or breastfeeding. Criteria for exclusion from the study: * Failure to attend three consecutive sessions of the exercise programme * Change in ongoing pharmacological treatment or discontinuation of pharmacological treatment * Development of a history of MS attacks or deterioration in health status
- Ankara, Turkey (Türkiye)