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Probiotic Intervention for People With Multiple Sclerosis

CompletedNA

Sponsor: Sheffield Hallam University

Conditions: Multiple Sclerosis

Interventions: Probiotic

Countries: United Kingdom

The goal of this single-arm, mixed methods trial is to learn if it is feasible and acceptable to take a probiotic for 12-weeks in people with Multiple Sclerosis. The main question\[s\] it aims to answer \[is/are\]: * Is it feasible and acceptable for people with MS to take a probiotic for 12-weeks? * Explore impact on health outcomes? Participants will. * Drink 70ml probiotic drink daily as prescribed for 12-weeks. * All data collection will be done remotely. * Before and after 12-weeks participants will complete an online questionnaire (Acceptability, lifestyle behaviour, symptoms, quality of life). * Provide a stool sample to analyse microbiome changes. * Take a short online cognitive test. * Participate in a focus group.

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Adults aged 18 years or over.
* Living in the United Kingdom.
* Self-reported clinical diagnosis of MS.

Exclusion Criteria:

* Symptom relapse or hospital admission in the prior four weeks.
* Rapidly progressing MS defined as two of more disabling relapses in the last year.
* Immunocompromised and requiring steroids (not including PwMS taking anti-CD20 monoclonal antibodies \[Ocrevus or Kesimpta\]).
* Type 2 diabetes, Cardiovascular disease, kidney disease, chronic gastrointestinal tract health issues.
* Pregnant or lactating.
* Dysphagia.
* Antibiotic use in the prior three months.
* Pro-biotic use in the prior four weeks.
* Use of food supplements which target gut health in the prior four weeks.
* Medically advised not to use a probiotic.

Locations (1)

Sheffield, South Yorkshire, United Kingdom