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Low-Dose Naltrexone For ME/CFS: Dose-Finding

Not Yet RecruitingPhase 2

Sponsor: University of Alabama at Birmingham

Conditions: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Interventions: Low-Dose Naltrexone, 1.5mg, Low-Dose Naltrexone, 3.0mg, Low-Dose Naltrexone, 4.5mg, Low-Dose Naltrexone, 6.0mg

Countries: United States

This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.

Eligibility overview

Sex: ALL

Age: 18 Years to 65 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* Between ages of 18 and 65
* Living in Alabama
* Meets ME-ICC criteria

Exclusion Criteria:

* Abnormal hepatic function
* Abnormal renal function
* Abnormal complete blood count
* Evidence of active or chronic systemic infection
* A1C \> 9.0%
* Current opioid analgesic use
* Pregnant or plans to become pregnant during the study participation period
* Auto-immune disorder
* Enrolled in other experimental treatment study

Locations (1)

Birmingham, Alabama, United States