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Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study

Not Yet RecruitingN/A

Sponsor: Mohamed Moshref abd alsattar

Conditions: NMO and MS

Interventions: Bedside cardiovascular reflex tests

To compare the frequency and patterns of autonomic dysfunction in patients with NMOSD and MS, and to investigate its correlations with clinical disability, radiological findings, fatigue, and quality of life parameters

Eligibility overview

Sex: ALL

Age: 18 Years to —

Healthy volunteers: No

Study type: OBSERVATIONAL

Eligibility criteria

Inclusion Criteria:

* Adult patients (≥18 years , both sexes.
* Confirmed diagnosis of NMOSD according to the 2015 International Consensus Criteria.
* Confirmed diagnosis of RRMS according to the 2024 McDonald diagnostic criteria.

Exclusion Criteria:

* Comorbidities affecting autonomic function (e.g., diabetes, Parkinsonism).
* Medications known to interfere with autonomic testing.
* Cognitive impairment precluding questionnaire completion.