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The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Sleep Health in Adults (Age 50+) With HIV

NCT07272863

Not Yet RecruitingNA

Sponsor: University of Alabama, Tuscaloosa

Conditions: Insomnia, Cognition, Aging, HIV

Interventions: BBTI, BMT

Countries: United States

The goal of this clinical trial is to examine the effects of a telephone-delivered Brief Behavioral Treatment Insomnia (BBTI) versus a Brief Mindfulness Treatment (BMT) on cognitive and sleep outcomes in older adults with HIV. The main questions it aims to answer are: What are the effects of BBTI vs BMT on self-reported and observed sleep outcomes in older adults with HIV and insomnia up to 1-year post-intervention? What are the effects of BBTI vs BMT on self-reported and observed cognitive comes in older adults with HIV and insomnia up to 1-year post-intervention? What is the association between Alzheimer's Disease biomarkers and sleep and cognitive outcomes in older adults with HIV receiving BBTI vs BMT? Participants will: * Complete 4 weeks of telephone-delivered BBTI or BMT * Attend baseline, post-intervention, and 1-year post in-person visits for sleep and cognitive assessments * Have blood collected at all three time points

Eligibility overview

Sex: ALL

Age: 50 Years to 99 Years

Healthy volunteers: No

Study type: INTERVENTIONAL

Eligibility criteria

Inclusion Criteria:

* must be age 50 or older
* have a DSM-5 diagnostic criteria for insomnia including sleep difficulty that occurs at least 3 times per week and has been a problem for at least 3 consecutive months (indicated on the Structured Clinical Interview for Sleep Disorders, SCISD) during telephone screening
* have a confirmed HIV diagnosis and a prescribed ART regimen for at least 12 months.

Exclusion Criteria:

* unable to speak English
* have a reported or documented (in medical records) diagnosis of AD or dementia
* have severe neurocognitive impairment (\>7 errors on the Short Portable Mental Status Questionnaire, SPMSQ) during telephone screening
* have a history of a stroke
* currently undergoing radiation/chemotherapy
* reports a history of brain trauma with loss of consciousness greater than 30 minutes
* have a learning disability
* have a documented diagnosis of sleep apnea (in medical records)
* reports use of a continuous positive airway pressure machine
* have been identified as high risk for moderate to severe sleep apnea (Snoring, Tiredness, Observed sleep apnea, Pressure, BMI, Age, Neck circumference, and Gender, STOP BANG ≥ 5) during telephone screening
* have restless leg syndrome and/or have narcolepsy
* have a documented history of bipolar disorder or psychotic disorder
* not be receiving efavirenz as part of their current ART regimen

Locations (2)

Birmingham, Alabama, United States
Tuscaloosa, Alabama, United States